Doxorubicin loaded on aminosilane modified superparamagnetic magnetic nanoparticles and its characterization

Document Type : Original Article


Department of Chemistry, Ardabil Branch, Islamic Azad University, Ardabil, Iran


In the past few decades, Magnetite (Fe3O4) nanoparticles have attracted growing research interest that this material has many
applications in medicine and drug delivery, Coated magnetic particles, called carriers, are very useful for delivering
chemotherapeutic drugs. In this work, Magnetite nanoparticles (NPs) were synthesized by co-precipitating Fe
2+ and Fe3+ in an
ammonia solution. Magnetite NPs coated with 3-aminopropyltriethoxysilane (APTES) were prepared by silanization. Then
Doxorubicin (DOX) drug was loaded at modified magnetic nanoparticles. The structural, morphological and magnetic properties of
as-prepared sample were characterization by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra, scanning electron
microscopy/energy dispersive x-ray analysis (SEM-EDAX) and magnetic measurements were investigated using vibrating sample
magnetometer (VSM). We demonstrate that the drug DOX is attached to the nanoparticles surface, that the binding of DOX to the
nanoparticles was confirmed by FT-IR analysis. The potential of doxorubicin against the cancer cells K562 was evaluated using the
MTT assay. That, cell culture experiments demonstrated the potential of these nanosystems as an effective dual targeting
nanoplatform for the delivery of anticancer drugs